Cluster Analysis in the COPDGene Study Identifies Subtypes of Smokers with Distinct Patterns of Airway Disease and Emphysema

BACKGROUND: There is notable heterogeneity in the clinical presentation of patients with COPD. To characterize this heterogeneity, we sought to identify subgroups of smokers by applying cluster analysis to data from the COPDGene Study. METHODS: We applied a clustering method, k-means, to data from 1...

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Detalhes bibliográficos
Main Authors: Castaldi, Peter J, Dy, Jennifer, Ross, James, Chang, Yale, Washko, George R, Curran-Everett, Douglas, Williams, Andre, Lynch, David A, Make, Barry J, Crapo, James D, Bowler, Russ P, Regan, Elizabeth A, Hokanson, John E, Kinney, Greg L, Han, Meilan K, Soler, Xavier, Ramsdell, Joseph W, Barr, R Graham, Foreman, Marilyn, van Beek, Edwin, Casaburi, Richard, Criner, Gerald J, Lutz, Sharon M, Rennard, Steven I, Santorico, Stephanie, Sciurba, Frank C, DeMeo, Dawn L, Hersh, Craig P, Silverman, Edwin K, Cho, Michael H
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004338/
https://ncbi.nlm.nih.gov/pubmed/24563194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2013-203601
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