Cluster Analysis in the COPDGene Study Identifies Subtypes of Smokers with Distinct Patterns of Airway Disease and Emphysema

BACKGROUND: There is notable heterogeneity in the clinical presentation of patients with COPD. To characterize this heterogeneity, we sought to identify subgroups of smokers by applying cluster analysis to data from the COPDGene Study. METHODS: We applied a clustering method, k-means, to data from 1...

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Main Authors: Castaldi, Peter J, Dy, Jennifer, Ross, James, Chang, Yale, Washko, George R, Curran-Everett, Douglas, Williams, Andre, Lynch, David A, Make, Barry J, Crapo, James D, Bowler, Russ P, Regan, Elizabeth A, Hokanson, John E, Kinney, Greg L, Han, Meilan K, Soler, Xavier, Ramsdell, Joseph W, Barr, R Graham, Foreman, Marilyn, van Beek, Edwin, Casaburi, Richard, Criner, Gerald J, Lutz, Sharon M, Rennard, Steven I, Santorico, Stephanie, Sciurba, Frank C, DeMeo, Dawn L, Hersh, Craig P, Silverman, Edwin K, Cho, Michael H
格式: Artigo
語言:Inglês
出版: 2014
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004338/
https://ncbi.nlm.nih.gov/pubmed/24563194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2013-203601
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