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Detection of Protein–Protein Interactions by Proximity-Driven S(N)Ar Reactions of Lysine-Linked Fluorophores
[Image: see text] Critical protein–protein interactions are ubiquitous in biology. To provide a new method to detect these interactions, we designed and synthesized fluorinated bromopyronins as molecular probes. These electrophilic compounds rapidly react with amines via a S(N)Ar mechanism to form m...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4004224/ https://ncbi.nlm.nih.gov/pubmed/24660775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja501253b |
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