Dual IGF-1R/InsR Inhibitor BMS-754807 Synergizes with Hormonal Agents in Treatment of Estrogen-Dependent Breast Cancer

Insulin-like growth factor (IGF) signaling has been implicated in the resistance to hormonal therapy in breast cancer. Using a model of postmenopausal, estrogen-dependent breast cancer, we investigated the antitumor effects of the dual IGF-1R/InsR tyrosine kinase inhibitor BMS-754807 alone and in co...

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Главные авторы: Hou, Xiaonan, Huang, Fei, Macedo, Luciana F., Harrington, Sean C., Reeves, Karen A., Greer, Ann, Finckenstein, Friedrich Graf, Brodie, Angela, Gottardis, Marco M., Carboni, Joan M., Haluska, Paul
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004036/
https://ncbi.nlm.nih.gov/pubmed/22042792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-1080
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