Loss of E-cadherin enhances IGF1-IGF1R pathway activation and sensitizes breast cancers to anti-IGF1R/InsR inhibitors

PURPOSE: Insulin-like growth factor 1 (IGF1) signaling regulates breast cancer initiation and progression and associated cancer phenotypes. We previously identified E-cadherin (CDH1) as a repressor of IGF1 signaling and in this study examined how loss of E-cadherin affects IGF1R signaling and respon...

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Bibliographic Details
Published in:Clin Cancer Res
Main Authors: Nagle, Alison M., Levine, Kevin M., Tasdemir, Nilgun, Scott, Julie A., Burlbaugh, Kara, Kehm, Justin, Katz, Tiffany A., Boone, David N., Jacobsen, Britta M., Atkinson, Jennifer M., Oesterreich, Steffi, Lee, Adrian V.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6821389/
https://ncbi.nlm.nih.gov/pubmed/29941485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0279
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