Synthesis and in vitro evaluation of [(18)F]BMS-754807: A potential PET ligand for IGF-1R

Radiosynthesis and in vitro evaluation of [(18)F](S)-1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[ 2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide ([(18)F]BMS-754807 or [(18)F]1) a specific IGF-1R inhibitor was performed. [(18)F]1 demonstrated specific bin...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Majo, Vattoly J., Arango, Victoria, Simpson, Norman R., Prabhakaran, Jaya, Kassir, Suham A., Underwood, Mark D., Bakalian, Mihran, Canoll, Peter, Mann, J. John, Dileep Kumar, J. S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820059/
https://ncbi.nlm.nih.gov/pubmed/23743281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.05.026
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