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Simultaneous TLR2 inhibition and TLR9 activation synergistically suppress tumor metastasis in mice
AIM: To develop a rational immunotherapy against tumor metastasis by combining a Toll-like-receptor 2 (TLR2)-neutralizing antibody with a TLR9 agonist CpG ODN, and then investigate the mechanism of action for this combinational regimen. METHODS: After mouse melanoma B16-F10 cell inoculation, female...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4003363/ https://ncbi.nlm.nih.gov/pubmed/22426694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.193 |
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