AGPAT9 suppresses cell growth, invasion and metastasis by counteracting acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancer

Human 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9) is the gene identified from adipose tissue in 2007. We found AGPAT9 expression was significantly higher in poorly invasive MCF7 human breast cancer cells than the highly invasive MDA-MB-231 cells. AGPAT9 significantly inhibited the prolif...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Fan, Shao-hua, Wang, Yan-yan, Wu, Zhi-yong, Zhang, Zi-feng, Lu, Jun, Li, Meng-qiu, Shan, Qun, Wu, Dong-mei, Sun, Chun-hui, Hu, Bin, Zheng, Yuan-lin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621899/
https://ncbi.nlm.nih.gov/pubmed/26110566
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