Simultaneous TLR2 inhibition and TLR9 activation synergistically suppress tumor metastasis in mice

AIM: To develop a rational immunotherapy against tumor metastasis by combining a Toll-like-receptor 2 (TLR2)-neutralizing antibody with a TLR9 agonist CpG ODN, and then investigate the mechanism of action for this combinational regimen. METHODS: After mouse melanoma B16-F10 cell inoculation, female...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yan, Jun, Hua, Fang, Liu, Han-zhi, Yang, Hong-zheng, Hu, Zhuo-wei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2012
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003363/
https://ncbi.nlm.nih.gov/pubmed/22426694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.193
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