NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro

AIM: NVP-BEZ235 is a novel dual PI3K/mTOR inhibitor and shows dramatic effects on gliomas. The aim of this study was to investigate the effects of NVP-BEZ235 on the radiosensitivity and autophagy of glioma stem cells (GSCs) in vitro. METHODS: Human GSCs (SU-2) were tested. The cell viability and sur...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Wen-juan, Long, Lin-mei, Yang, Neng, Zhang, Qing-qing, Ji, Wen-jun, Zhao, Jiang-hu, Qin, Zheng-hong, Wang, Zhong, Chen, Gang, Liang, Zhong-qin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2013
Schlagworte:
Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002877/
https://ncbi.nlm.nih.gov/pubmed/23603977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.22
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