Radiosensitization of Glioblastoma Cell Lines by the Dual PI3K and mTOR Inhibitor NVP-BEZ235 Depends on Drug-Irradiation Schedule

Previous studies have shown that the dual phosphatidylinositide 3-kinase/mammalian target of rapamycin (PI3K/mTOR) inhibitor NVP-BEZ235 radiosensitizes tumor cells if added shortly before ionizing radiation (IR) and kept in culture medium thereafter. The present study explores the impact of inhibito...

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Detalhes bibliográficos
Main Authors: Kuger, Sebastian, Graus, Dorothea, Brendtke, Rico, Günther, Nadine, Katzer, Astrid, Lutyj, Paul, Polat, Bülent, Chatterjee, Manik, Sukhorukov, Vladimir L, Flentje, Michael, Djuzenova, Cholpon S
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610553/
https://ncbi.nlm.nih.gov/pubmed/23544169
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