CPU86017, a berberine derivative, attenuates cardiac failure through normalizing calcium leakage and downregulated phospholamban and exerting antioxidant activity

AIM: To investigate whether CPU86017, a berberine derivative, attenuates heart failure by blocking calcium influx and exerting its antioxidant activity. METHODS: Myocardial infarction was induced in male Sprague-Dawley rats for 17 d followed by isoproterenol (ISO) (5 mg/kg, sc) treatment for 5 d to...

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Autores principales: Qi, Min-you, Feng, Yu, Dai, De-zai, Li, Na, Cheng, Yu-si, Dai, Yin
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2010
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002834/
https://ncbi.nlm.nih.gov/pubmed/20139899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2009.180
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