Hypoxia/oxidative stress alters the pharmacokinetics of CPU86017-RS through mitochondrial dysfunction and NADPH oxidase activation

AIM: Hypoxia/oxidative stress can alter the pharmacokinetics (PK) of CPU86017-RS, a novel antiarrhythmic agent. The aim of this study was to investigate the mechanisms underlying the alteration of PK of CPU86017-RS by hypoxia/oxidative stress. METHODS: Male SD rats exposed to normal or intermittent...

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Hlavní autoři: Gao, Jie, Ding, Xuan-sheng, Zhang, Yu-mao, Dai, De-zai, Liu, Mei, Zhang, Can, Dai, Yin
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002573/
https://ncbi.nlm.nih.gov/pubmed/24122013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.94
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