Stereoselective binding of doxazosin enantiomers to plasma proteins from rats, dogs and humans in vitro

AIM: (±)Doxazosin is a long-lasting inhibitor of α1-adrenoceptors that is widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms. In this study we investigated the stereoselective binding of doxazosin enantiomers to the plasma proteins of rats, dogs and humans in vitro. M...

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Bibliographic Details
Main Authors: Sun, Jia-an, Kong, De-zhi, Zhen, Ya-qin, Li, Qing, Zhang, Wei, Zhang, Jiang-hua, Yin, Zhi-wei, Ren, Lei-ming
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2013
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002564/
https://ncbi.nlm.nih.gov/pubmed/24241343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.120
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