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Stereoselective disposition of ibuprofen enantiomers in infants
The pharmacokinetics of the enantiomers of ibuprofen were investigated after oral administration of a single 7.6 ± 0.3 mg kg(-1) dose of the racemate in 11 infants. Mean (± s.d.) half-lives were 1.6 ± 0.5 h for S(+) and 1.5 ± 0.5 h for R(-) and mean (± s.d.) AUC values were 31.5 ± 14.3 mg l(-1) h fo...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1994
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1364783/ https://ncbi.nlm.nih.gov/pubmed/7833229 |
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