(−)Doxazosin is a necessary component for the hypotensive effect of (±)doxazosin during long-term administration in conscious rats

AIM: Doxazosin is a racemic mixture of (−)doxazosin and (+)doxazosin that is currently used as an add-on therapy for hypertension. In this study we investigated the contribution of each enantiomer to the hypotensive action of long-term administration of (±)doxazosin in conscious rats. METHODS: Blood...

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Hlavní autoři: Zhao, Jing, Kong, De-zhi, Li, Qing, Zhen, Ya-qin, Wang, Miao, Zhao, Yan, Wang, Dong-kai, Ren, Lei-ming
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4075743/
https://ncbi.nlm.nih.gov/pubmed/24335843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.154
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