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Discovery of potent β-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybrids
AIM: The aim of this study was to design and synthesize a series of high activity compounds against aspartyl protease β-secretase (BACE-1) bearing hydroxyethylene (HE) framework. METHODS: First, we designed the small library based on our previous work and rational analysis. Subsequently, thirteen co...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4002469/ https://ncbi.nlm.nih.gov/pubmed/19169270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2008.26 |
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