Discovery of Sulforaphane as a Potent BACE1 Inhibitor Based on Kinetics and Computational Studies

BACE1 is the rate-limiting enzyme involved in the production and deposition of β-amyloid (Aβ). Since neurotoxic Aβ plays a critical role in Alzheimer’s disease (AD) pathogenesis, BACE1 has emerged as a key target for preventing AD. In the present study, the potential of sulforaphane, an isothiocyana...

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Vydáno v:Nutrients
Hlavní autoři: Youn, Kumju, Yoon, Jeong-Hyun, Lee, Nayoung, Lim, Gyutae, Lee, Jinhyuk, Sang, Shengmin, Ho, Chi-Tang, Jun, Mira
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7601397/
https://ncbi.nlm.nih.gov/pubmed/33023225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nu12103026
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