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Discovery of Sulforaphane as a Potent BACE1 Inhibitor Based on Kinetics and Computational Studies
BACE1 is the rate-limiting enzyme involved in the production and deposition of β-amyloid (Aβ). Since neurotoxic Aβ plays a critical role in Alzheimer’s disease (AD) pathogenesis, BACE1 has emerged as a key target for preventing AD. In the present study, the potential of sulforaphane, an isothiocyana...
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| Veröffentlicht in: | Nutrients |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
MDPI
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7601397/ https://ncbi.nlm.nih.gov/pubmed/33023225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nu12103026 |
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