After Embedding in Membranes Antiapoptotic Bcl-XL Protein Binds Both Bcl-2 Homology Region 3 and Helix 1 of Proapoptotic Bax Protein to Inhibit Apoptotic Mitochondrial Permeabilization

Bcl-XL binds to Bax, inhibiting Bax oligomerization required for mitochondrial outer membrane permeabilization (MOMP) during apoptosis. How Bcl-XL binds to Bax in the membrane is not known. Here, we investigated the structural organization of Bcl-XL·Bax complexes formed in the MOM, including the bin...

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Bibliografiske detaljer
Main Authors: Ding, Jingzhen, Mooers, Blaine H. M., Zhang, Zhi, Kale, Justin, Falcone, Domina, McNichol, Jamie, Huang, Bo, Zhang, Xuejun C., Xing, Chengguo, Andrews, David W., Lin, Jialing
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002096/
https://ncbi.nlm.nih.gov/pubmed/24616095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.552562
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