Natural Diterpenoid Compound Elevates Expression of Bim Protein, Which Interacts with Antiapoptotic Protein Bcl-2, Converting It to Proapoptotic Bax-like Molecule

Overwhelming evidence indicates that Bax and Bak are indispensable for mediating cytochrome c release from mitochondria during apoptosis. Here we report a Bax/Bak-independent mechanism of cytochrome c release and apoptosis. We identified a natural diterpenoid compound that induced apoptosis in bax/b...

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Detalhes bibliográficos
Main Authors: Zhao, Lixia, He, Feng, Liu, Haiyang, Zhu, Yushan, Tian, Weili, Gao, Ping, He, Hongping, Yue, Wen, Lei, Xiaobo, Ni, Biyun, Wang, Xiaohui, Jin, Haijing, Hao, Xiaojiang, Lin, Jialing, Chen, Quan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256916/
https://ncbi.nlm.nih.gov/pubmed/22065578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.264481
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