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14‐3‐3‐β and ‐ε contribute to activation of the osmoprotective transcription factor NFAT5 by increasing its protein abundance and its transactivating activity

Having previously found that high NaCl causes rapid exit of 14‐3‐3 isoforms from the nucleus, we used siRNA‐mediated knockdown to test whether 14‐3‐3s contribute to the high NaCl‐induced increase in the activity of the osmoprotective transcription factor NFAT5. We find that, when NaCl is elevated, k...

詳細記述

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書誌詳細
主要な著者: Izumi, Yuichiro, Burg, Maurice B., Ferraris, Joan D.
フォーマット: Artigo
言語:Inglês
出版事項: Wiley Periodicals, Inc. 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001879/
https://ncbi.nlm.nih.gov/pubmed/24771694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12000
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