14‐3‐3‐β and ‐ε contribute to activation of the osmoprotective transcription factor NFAT5 by increasing its protein abundance and its transactivating activity

Having previously found that high NaCl causes rapid exit of 14‐3‐3 isoforms from the nucleus, we used siRNA‐mediated knockdown to test whether 14‐3‐3s contribute to the high NaCl‐induced increase in the activity of the osmoprotective transcription factor NFAT5. We find that, when NaCl is elevated, k...

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Bibliographic Details
Main Authors: Izumi, Yuichiro, Burg, Maurice B., Ferraris, Joan D.
Format: Artigo
Language:Inglês
Published: Wiley Periodicals, Inc. 2014
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001879/
https://ncbi.nlm.nih.gov/pubmed/24771694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12000
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