Mice with targeted inactivation of Ppap2b in endothelial and hematopoietic cells display enhanced vascular inflammation and permeability

OBJECTIVE: Lipid phosphate phosphatase 3 (LPP3), encoded by the PPAP2B gene, is an integral membrane enzyme that dephosphorylates, and thereby terminates, the G-protein-coupled receptor-mediated signaling actions of lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P). LPP3 is essential for...

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Autors principals: Panchatcharam, Manikandan, Salous, Abdel K., Brandon, Jason, Miriyala, Sumitra, Wheeler, Jessica, Patil, Pooja, Sunkara, Manjula, Morris, Andrew J., Escalante-Alcalde, Diana, Smyth, Susan S.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001868/
https://ncbi.nlm.nih.gov/pubmed/24504738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.113.302335
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