Cardiac-specific inactivation of LPP3 in mice leads to myocardial dysfunction and heart failure

Lipid Phosphate phosphatase 3 (LPP3), encoded by the Plpp3 gene, is an enzyme that dephosphorylates the bioactive lipid mediator lysophosphatidic acid (LPA). To study the role of LPP3 in the myocardium, we generated a cardiac specific Plpp3 deficient mouse strain. Although these mice were viable at...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Chandra, Mini, Escalante-Alcalde, Diana, Bhuiyan, Md. Shenuarin, Orr, Anthony Wayne, Kevil, Christopher, Morris, Andrew J., Nam, Hyung, Dominic, Paari, McCarthy, Kevin J., Miriyala, Sumitra, Panchatcharam, Manikandan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635346/
https://ncbi.nlm.nih.gov/pubmed/28982073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.09.015
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