The structured core domain of αB-crystallin can prevent amyloid fibrillation and associated toxicity

Mammalian small heat-shock proteins (sHSPs) are molecular chaperones that form polydisperse and dynamic complexes with target proteins, serving as a first line of defense in preventing their aggregation into either amorphous deposits or amyloid fibrils. Their apparently broad target specificity make...

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Bibliographische Detailangaben
Hauptverfasser: Hochberg, Georg K. A., Ecroyd, Heath, Liu, Cong, Cox, Dezerae, Cascio, Duilio, Sawaya, Michael R., Collier, Miranda P., Stroud, James, Carver, John A., Baldwin, Andrew J., Robinson, Carol V., Eisenberg, David S., Benesch, Justin L. P., Laganowsky, Arthur
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4000792/
https://ncbi.nlm.nih.gov/pubmed/24711386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322673111
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