The structured core domain of αB-crystallin can prevent amyloid fibrillation and associated toxicity

Mammalian small heat-shock proteins (sHSPs) are molecular chaperones that form polydisperse and dynamic complexes with target proteins, serving as a first line of defense in preventing their aggregation into either amorphous deposits or amyloid fibrils. Their apparently broad target specificity make...

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Hlavní autoři: Hochberg, Georg K. A., Ecroyd, Heath, Liu, Cong, Cox, Dezerae, Cascio, Duilio, Sawaya, Michael R., Collier, Miranda P., Stroud, James, Carver, John A., Baldwin, Andrew J., Robinson, Carol V., Eisenberg, David S., Benesch, Justin L. P., Laganowsky, Arthur
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4000792/
https://ncbi.nlm.nih.gov/pubmed/24711386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322673111
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