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N- and C-terminal regions of αB-crystallin and Hsp27 mediate inhibition of amyloid nucleation, fibril binding, and fibril disaggregation

Small heat-shock proteins (sHSPs) are ubiquitously expressed molecular chaperones that inhibit amyloid fibril formation; however, their mechanisms of action remain poorly understood. sHSPs comprise a conserved α-crystallin domain flanked by variable N- and C-terminal regions. To investigate the func...

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書目詳細資料
發表在:J Biol Chem
Main Authors: Selig, Emily E., Zlatic, Courtney O., Cox, Dezerae, Mok, Yee-Foong, Gooley, Paul R., Ecroyd, Heath, Griffin, Michael D. W.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7380184/
https://ncbi.nlm.nih.gov/pubmed/32417755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012748
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