The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity

Proteostasis, or protein homeostasis, encompasses the maintenance of the conformational and functional integrity of the proteome and involves an integrated network of cellular pathways. Molecular chaperones, such as the small heat shock proteins (sHsps), are key elements of the proteostasis network...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Cox, Dezerae, Whiten, Daniel R., Brown, James W. P., Horrocks, Mathew H., San Gil, Rebecca, Dobson, Christopher M., Klenerman, David, van Oijen, Antoine M., Ecroyd, Heath
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5868268/
https://ncbi.nlm.nih.gov/pubmed/29382725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.813865
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