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The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity
Proteostasis, or protein homeostasis, encompasses the maintenance of the conformational and functional integrity of the proteome and involves an integrated network of cellular pathways. Molecular chaperones, such as the small heat shock proteins (sHsps), are key elements of the proteostasis network...
Guardat en:
| Publicat a: | J Biol Chem |
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| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5868268/ https://ncbi.nlm.nih.gov/pubmed/29382725 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.813865 |
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