Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function

Small heat shock proteins alphaA and alphaB crystallin form highly polydisperse oligomers that frustrate protein aggregation, crystallization, and amyloid formation. Here, we present the crystal structures of truncated forms of bovine alphaA crystallin (AAC(59–163)) and human alphaB crystallin (ABC(...

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Main Authors: Laganowsky, Arthur, Benesch, Justin L P, Landau, Meytal, Ding, Linlin, Sawaya, Michael R, Cascio, Duilio, Huang, Qingling, Robinson, Carol V, Horwitz, Joseph, Eisenberg, David
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868245/
https://ncbi.nlm.nih.gov/pubmed/20440841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.380
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