Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function

Small heat shock proteins alphaA and alphaB crystallin form highly polydisperse oligomers that frustrate protein aggregation, crystallization, and amyloid formation. Here, we present the crystal structures of truncated forms of bovine alphaA crystallin (AAC(59–163)) and human alphaB crystallin (ABC(...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Laganowsky, Arthur, Benesch, Justin L P, Landau, Meytal, Ding, Linlin, Sawaya, Michael R, Cascio, Duilio, Huang, Qingling, Robinson, Carol V, Horwitz, Joseph, Eisenberg, David
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Wiley Subscription Services, Inc., A Wiley Company 2010
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868245/
https://ncbi.nlm.nih.gov/pubmed/20440841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.380
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