Unified Polymerization Mechanism for the Assembly of ASC-dependent Inflammasomes

Inflammasomes elicit host defense inside cells by activating caspase-1 for cytokine maturation and cell death. AIM2 and NLRP3 are representative sensor proteins in two major families of inflammasomes. The adaptor protein ASC bridges the sensor proteins and caspase-1 to form ternary inflammasome comp...

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Main Authors: Lu, Alvin, Magupalli, VenkatGiri, Ruan, Jianbin, Yin, Qian, Atianand, Maninjay K., Vos, Matthijn, Schröder, Gunnar F., Fitzgerald, Katherine A., Wu, Hao, Egelman, Edward H.
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4000066/
https://ncbi.nlm.nih.gov/pubmed/24630722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.02.008
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