Emergence of constitutively active estrogen receptor-α mutations in pretreated advanced estrogen receptor positive breast cancer

PURPOSE: We undertook this study to determine the prevalence of estrogen receptor (ER) α (ESR1) mutations throughout the natural history of hormone dependent breast cancer and to delineate the functional roles of the most commonly detected alterations. EXPERIMENTAL DESIGN: We studied a total of 249...

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Main Authors: Jeselsohn, Rinath, Yelensky, Roman, Buchwalter, Gilles, Frampton, Garrett, Meric-Bernstam, Funda, Gonzalez-Angulo, Ana Maria, Ferrer-Lozano, Jaime, Perez-Fidalgo, Jose A., Cristofanilli, Massimo, Gómez, Henry, Arteaga, Carlos L., Giltnane, Jennifer, Balko, Justin M., Cronin, Maureen T, Jarosz, Mirna, Sun, James, Hawryluk, Matthew, Lipson, Doron, Otto, Geoff, Ross, Jeffrey S, Dvir, Addie, Soussan-Gutman, Lior, Wolf, Ido, Rubinek, Tamar, Gilmore, Lauren, Schnitt, Stuart, Come, Steven E., Pusztai, Lajos, Stephens, Philip, Brown, Myles, Miller, Vincent A.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3998833/
https://ncbi.nlm.nih.gov/pubmed/24398047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-2332
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