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Peptides containing a consensus Ras binding sequence from Raf-1 and theGTPase activating protein NF1 inhibit Ras function.

A key event in Ras-mediated signal transduction and transformation involves Ras interaction with its downstream effector targets. Although substantial evidence has established that the Raf-1 serine/threonine kinase is a critical effector of Ras function, there is increasing evidence that Ras functio...

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Autori principali: Clark, G J, Drugan, J K, Terrell, R S, Bradham, C, Der, C J, Bell, R M, Campbell, S
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1996
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC39983/
https://ncbi.nlm.nih.gov/pubmed/8643674
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