A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function.
Ras and Raf-1 are key proteins involved in the transmission of developmental and proliferative signals generated by receptor and nonreceptor tyrosine kinases. Genetic and biochemical studies demonstrate that Raf-1 functions downstream of Ras in many signaling pathways. Although Raf-1 directly associ...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1994
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44121/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8016101/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.13.5982 |
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