A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function.

Ras and Raf-1 are key proteins involved in the transmission of developmental and proliferative signals generated by receptor and nonreceptor tyrosine kinases. Genetic and biochemical studies demonstrate that Raf-1 functions downstream of Ras in many signaling pathways. Although Raf-1 directly associ...

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Main Authors: Fabian, J R, Vojtek, A B, Cooper, J A, Morrison, D K
Format: Artigo
Sprog:Inglês
Udgivet: 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC44121/
https://ncbi.nlm.nih.gov/pubmed/8016101
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