Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells.

The potent transforming activity of membrane-targeted Raf-1 (Raf-CAAX) suggests that Ras transformation is triggered primarily by a Ras-mediated translocation of Raf-1 to the plasma membrane. However, whereas constitutively activated mutants of Ras [H-Ras(61L) and K-Ras4B(12V)] and Raf-1 (DeltaRaf-2...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Oldham, S M, Clark, G J, Gangarosa, L M, Coffey, R J, Der, C J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38910/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8692920/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.14.6924
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!