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Single cell imaging of Bruton's Tyrosine Kinase using an irreversible inhibitor
A number of Bruton's tyrosine kinase (BTK) inhibitors are currently in development, yet it has been difficult to visualize BTK expression and pharmacological inhibition in vivo in real time. We synthesized a fluorescent, irreversible BTK binder based on the drug Ibrutinib and characterized its...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3998017/ https://ncbi.nlm.nih.gov/pubmed/24759210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04782 |
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