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Second-generation inhibitors of Bruton tyrosine kinase
Bruton tyrosine kinase (BTK) is a critical effector molecule for B cell development and plays a major role in lymphoma genesis. Ibrutinib is the first-generation BTK inhibitor. Ibrutinib has off-target effects on EGFR, ITK, and Tec family kinases, which explains the untoward effects of ibrutinib. Re...
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| Publicado en: | J Hematol Oncol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BioMed Central
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5010774/ https://ncbi.nlm.nih.gov/pubmed/27590878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-016-0313-y |
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