Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication

The ability of PRC1 and PRC2 to promote proliferation is a main feature that links polycomb (PcG) activity to cancer. PcGs silence the expression of the tumour suppressor locus Ink4a/Arf, whose products positively regulate pRb and p53 functions. Enhanced PcG activity is a frequent feature of human t...

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Autori principali: Piunti, Andrea, Rossi, Alessandra, Cerutti, Aurora, Albert, Mareike, Jammula, Sriganesh, Scelfo, Andrea, Cedrone, Laura, Fragola, Giulia, Olsson, Linda, Koseki, Haruhiko, Testa, Giuseppe, Casola, Stefano, Helin, Kristian, di Fagagna, Fabrizio d’Adda, Pasini, Diego
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3996544/
https://ncbi.nlm.nih.gov/pubmed/24728135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4649
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