Tyrosine-Mutant AAV8 Delivery of Human MERTK Provides Long-Term Retinal Preservation in RCS Rats

PURPOSE. The absence of Mertk in RCS rats results in defective RPE phagocytosis, accumulation of outer segment (OS) debris in the subretinal space, and subsequent death of photoreceptors. Previous research utilizing Mertk gene replacement therapy in RCS rats provided proof of concept for treatment o...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Deng, Wen-Tao, Dinculescu, Astra, Li, Qiuhong, Boye, Sanford L., Li, Jie, Gorbatyuk, Marina S., Pang, Jijing, Chiodo, Vince A., Matthes, Michael T., Yasumura, Douglas, Liu, Li, Alkuraya, Fowzan S., Zhang, Kang, Vollrath, Douglas, LaVail, Matthew M., Hauswirth, William W.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Association for Research in Vision and Ophthalmology 2012
Témata:
Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3995567/
https://ncbi.nlm.nih.gov/pubmed/22408006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.11-8831
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky