Cdc2-Like Kinase 2 Suppresses Hepatic Fatty Acid Oxidation and Ketogenesis Through Disruption of the PGC-1α and MED1 Complex

Hepatic ketogenesis plays an important role in catabolism of fatty acids during fasting along with dietary lipid overload, but the mechanisms regulating this process remain poorly understood. Here, we show that Cdc2-like kinase 2 (Clk2) suppresses fatty acid oxidation and ketone body production duri...

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Main Authors: Tabata, Mitsuhisa, Rodgers, Joseph T., Hall, Jessica A., Lee, Yoonjin, Jedrychowski, Mark P., Gygi, Steven P., Puigserver, Pere
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2014
Teme:
Metabolism
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3994960/
https://ncbi.nlm.nih.gov/pubmed/24458359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-1304
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