Tissue-Specific Inactivation of Type 2 Deiodinase Reveals Multilevel Control of Fatty Acid Oxidation by Thyroid Hormone in the Mouse

Type 2 deiodinase (D2) converts the prohormone thyroxine (T4) to the metabolically active molecule 3,5,3′-triiodothyronine (T3), but its global inactivation unexpectedly lowers the respiratory exchange rate (respiratory quotient [RQ]) and decreases food intake. Here we used FloxD2 mice to generate s...

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Autors principals: Fonseca, Tatiana L., Werneck-De-Castro, Joao Pedro, Castillo, Melany, Bocco, Barbara M.L.C., Fernandes, Gustavo W., McAninch, Elizabeth A., Ignacio, Daniele L., Moises, Caio C.S., Ferreira, Alexandre, Gereben, Balázs, Bianco, Antonio C.
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2014
Matèries:
Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3994955/
https://ncbi.nlm.nih.gov/pubmed/24487027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-1768
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