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GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN
Glucose-regulated protein 78 (GRP78), a molecular chaperone widely elevated in human cancers, is critical for endoplasmic reticulum (ER) protein folding, stress signaling and PI3K/AKT activation. Genetic knockout models of GRP78 revealed that GRP78 maintains homeostasis of metabolic organs, includin...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3994182/ https://ncbi.nlm.nih.gov/pubmed/24141775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.437 |
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