GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN

Glucose-regulated protein 78 (GRP78), a molecular chaperone widely elevated in human cancers, is critical for endoplasmic reticulum (ER) protein folding, stress signaling and PI3K/AKT activation. Genetic knockout models of GRP78 revealed that GRP78 maintains homeostasis of metabolic organs, includin...

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Hlavní autoři: Chen, Wan-Ting, Zhu, Genyuan, Pfaffenbach, Kyle, Kanel, Gary, Stiles, Bangyan, Lee, Amy S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3994182/
https://ncbi.nlm.nih.gov/pubmed/24141775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.437
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