Enhancers Are Major Targets for Murine Leukemia Virus Vector Integration

Retroviral vectors have been used in successful gene therapies. However, in some patients, insertional mutagenesis led to leukemia or myelodysplasia. Both the strong promoter/enhancer elements in the long terminal repeats (LTRs) of murine leukemia virus (MLV)-based vectors and the vector-specific in...

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Detalhes bibliográficos
Main Authors: De Ravin, Suk See, Su, Ling, Theobald, Narda, Choi, Uimook, Macpherson, Janet L., Poidinger, Michael, Symonds, Geoff, Pond, Susan M., Ferris, Andrea L., Hughes, Stephen H., Malech, Harry L., Wu, Xiaolin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993722/
https://ncbi.nlm.nih.gov/pubmed/24501411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00011-14
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