Simian immundeficiency virus lentivector corrects human X-linked chronic granulomatous disease in the NOD/SCID mouse xenograft

X-linked chronic granulomatous disease (X-CGD) is a primary immunodeficiency caused by mutations in the phagocyte NADPH oxidase catalytic subunit gp91(phox). Gene therapy targeting hematopoietic stem cells (HSCs) can correct CGD, but permanent correction remains a challenge. Lentiviral vectors have...

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Main Authors: Naumann, Nora, De Ravin, Suk See, Choi, Uimook, Moayeri, Morvarid, Whiting-Theobald, Narda, Linton, Gilda F., Ikeda, Yasuhiro, Malech, Harry L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696134/
https://ncbi.nlm.nih.gov/pubmed/17728796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.gt.3303010
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