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Simian immundeficiency virus lentivector corrects human X-linked chronic granulomatous disease in the NOD/SCID mouse xenograft
X-linked chronic granulomatous disease (X-CGD) is a primary immunodeficiency caused by mutations in the phagocyte NADPH oxidase catalytic subunit gp91(phox). Gene therapy targeting hematopoietic stem cells (HSCs) can correct CGD, but permanent correction remains a challenge. Lentiviral vectors have...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2696134/ https://ncbi.nlm.nih.gov/pubmed/17728796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.gt.3303010 |
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