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TRF2-Tethered TIN2 Can Mediate Telomere Protection by TPP1/POT1
The shelterin protein TIN2 is required for the telomeric accumulation of TPP1/POT1 heterodimers and for the protection of telomeres by the POT1 proteins (POT1a and POT1b in the mouse). TIN2 also binds to TRF1 and TRF2, improving the telomeric localization of TRF2 and its function. Here, we ask wheth...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3993560/ https://ncbi.nlm.nih.gov/pubmed/24469404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01052-13 |
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