Pharmacokinetic and Safety Analyses of Tenofovir and Tenofovir-Emtricitabine Vaginal Tablets in Pigtailed Macaques

Vaginal rapidly disintegrating tablets (RDTs) containing tenofovir (TFV) or TFV and emtricitabine (FTC) were evaluated for safety and pharmacokinetics in pigtailed macaques. Two separate animal groups (n = 4) received TFV (10 mg) or TFV-FTC (10 mg each) RDTs, administered near the cervix. A third gr...

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Hlavní autoři: Pereira, Lara E., Clark, Meredith R., Friend, David R., Garber, David A., McNicholl, Janet M., Hendry, R. Michael, Doncel, Gustavo F., Smith, James M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993262/
https://ncbi.nlm.nih.gov/pubmed/24566178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02336-13
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