Intrapulmonary Posaconazole Penetration at the Infection Site in an Immunosuppressed Murine Model of Invasive Pulmonary Aspergillosis Receiving Oral Prophylactic Regimens

Adequate penetration to the infection/colonization site is crucial to attain optimal efficacy of posaconazole against Aspergillus fumigatus diseases. We evaluated posaconazole exposure in pulmonary epithelial lining fluid (ELF) in a murine model of invasive pulmonary aspergillosis. The posaconazole...

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Hlavní autoři: Seyedmousavi, Seyedmojtaba, Brüggemann, Roger J. M., Melchers, Willem J. G., Verweij, Paul E., Mouton, Johan W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993253/
https://ncbi.nlm.nih.gov/pubmed/24566183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00053-14
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