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Building the bacterial orisome: high affinity DnaA recognition plays a role in setting the conformation of oriC DNA

During assembly of the E. coli pre-replicative complex (pre-RC), initiator DnaA oligomers are nucleated from three widely separated high affinity DnaA recognition sites in oriC. Oligomer assembly is then guided by low affinity DnaA recognition sites, but is also regulated by a switch-like conformati...

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Detalhes bibliográficos
Main Authors: Kaur, Gulpreet, Vora, Mansi P., Czerwonka, Christopher A., Rozgaja, Tania A., Grimwade, Julia E., Leonard, Alan C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992943/
https://ncbi.nlm.nih.gov/pubmed/24443848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.12525
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