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Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A

Ubiquitination of misfolded proteins, a common feature of many neurodegenerative diseases, is mediated by different lysine (K) residues in ubiquitin and alters the levels of toxic proteins. In Huntington disease, polyglutamine expansion causes N-terminal huntingtin (Htt) to misfold, inducing neurode...

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Main Authors: Bhat, Kavita P., Yan, Sen, Wang, Chuan-En, Li, Shihua, Li, Xiao-Jiang
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992696/
https://ncbi.nlm.nih.gov/pubmed/24706802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402215111
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