The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation

Caveolin-1 (CAV1), the major constituent of caveolae, plays a pivotal role in various cellular biological functions, including cancer and inflammation. The ubiquitin/proteasomal pathway is known to contribute to the regulation of CAV1 expression, but the ubiquitin ligase responsible for CAV1 protein...

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Vydáno v:Nat Commun
Hlavní autoři: Lee, Chih-Yuan, Lai, Ting-Yu, Tsai, Meng-Kun, Chang, Yung-Chi, Ho, Yu-Hsin, Yu, I-Shing, Yeh, Tzu-Wen, Chou, Chih-Chang, Lin, You-Sheng, Lawrence, Toby, Hsu, Li-Chung
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472178/
https://ncbi.nlm.nih.gov/pubmed/28593998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15502
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